Acquisition of high-level mupirocin resistance in CoNS following nasal decolonization with mupirocin

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Acquisition of high-level mupirocin resistance in CoNS following nasal decolonization with mupirocin.

OBJECTIVES The association between mupirocin use and plasmid-based high-level resistance development mediated through mupA in CoNS has not been quantified. We determined acquisition of mupirocin resistance in Staphylococcus aureus and CoNS in surgery patients treated peri-operatively with mupirocin. PATIENTS AND METHODS Patients admitted for surgery were treated with nasal mupirocin ointment ...

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Patient experience with mupirocin or povidone-iodine nasal decolonization.

Led by the federal government, the payers of health care are enacting policies designed to base provider reimbursement on the quality of care they render. This study evaluated and compared patient experiences and satisfaction with nasal decolonization with either nasal povidone-iodine (PI) or nasal mupirocin ointment (MO). A total of 1903 patients were randomized to undergo preoperative nasal d...

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Diversity of staphylococci exhibiting high-level resistance to mupirocin.

Plasmids mediating high-level resistance to mupirocin (MIC greater than 1000 mg/L) in staphylococci from various sources were studied by restriction endonuclease cleavage. Several patterns were obtained but six plasmids isolated from various Staphylococcus aureus and S. epidermidis strains were indistinguishable. The diversity and spread of these plasmids is illustrated.

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Emergence of high-level mupirocin resistance in coagulase-negative staphylococci associated with increased short-term mupirocin use.

In our hospital, mupirocin has increasingly been used for peri-operative decolonization of Staphylococcus aureus. The target for mupirocin is isoleucyl tRNA synthetase (ileS). High-level resistance to mupirocin is conferred by acquisition of plasmids expressing a distinct ileS gene (ileS2). Here we evaluated the longitudinal trends in high-level mupirocin resistance in coagulase-negative staphy...

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Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospects

Staphylococcus aureus in the nose is a risk factor for endogenous staphylococcal infection. UK guidelines recommend the use of mupirocin for nasal decolonization in certain groups of patients colonized with methicillin-resistant S. aureus (MRSA). Mupirocin is effective at removing S. aureus from the nose over a few weeks, but relapses are common within several months. There are only a few prosp...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2014

ISSN: 0305-7453,1460-2091

DOI: 10.1093/jac/dku522